In order to obtain baseline oral pharmacokinetics, safety, and efficacy of cannabidiol (CBD) for the treatment of osteoarthritis in dogs, single-dose administration was performed using two different doses of CBD enriched (2 and 8 mg/kg) oil. A randomized placebo-controlled, veterinarian, and owner blinded, cross-over study was conducted.
Dogs received each of two treatments: CBD oil (2 mg/kg) or placebo oil every twelve hours. Each treatment lasted for four weeks with a two-week washout period. Baseline veterinary assessment and owner questionnaires were completed before initiating each treatment and at weeks 2 and 4.
Hematology, serum chemistry and physical examinations were performed at each visit. Pharmacokinetics revealed an elimination half-life of 4.2 hours at both doses and no observable side effects. Clinically, canine brief pain inventory and Hudson activity scores showed a significant decrease in pain and increase in activity with CBD oil. Veterinary assessment also showed decreased pain during CBD treatment.
No side effects were reported by owners, however, serum chemistry showed an increase in alkaline phosphatase during CBD treatment. Clinically, this study suggests that 2 mg/kg of CBD twice daily can help increase comfort and activity in dogs with osteoarthritis.
Read more at the link below: